Using modern genomics to better understand the causes of gastrointestinal and respiratory disease in cats
GP West Fund
Area of study
Principal investigator: Alan Radford
The syndromes of respiratory disease and gastrointestinal disease represent significant health and welfare burdens to cats, both owned and in shelters. There is a lack of genetic sequence information for known feline pathogens associated with these syndromes, especially when compared to equivalent pathogens in other species such as the dog.
The project aimed to use a technique called next generation sequencing (NGS) to better understand the role of known and yet-to-be-identified infectious agents in feline respiratory and gastrointestinal disease. To achieve this aim they sequenced 60 samples from cats with signs of either respiratory or gastro-intestinal disease. They also obtained 30 full-length or near full-length genomes from 7 viral pathogens and partial sequences from many more viruses and bacteria.
You can read a more detailed process of the project, and its key findings, in the report below.